Largo High School teacher Christina Reszetar faces felony child abuse charges.
Officers said that the math teacher became aggressive because four students refused to wear their face masks properly in the classroom.
Reszetar allegedly sprayed aerosol disinfectant in the students faces and bodies.
Reszetar was booked into the Pinellas County jail on Wednesday and charged with four counts of felony child abuse with great bodily harm.
The 51-year-old teacher appeared before a judge on Thursday.
Reszetar told the judge she teaches Learning Disabled Math at Largo High School and has been teaching for 21 years, 18 of them at Largo High School.